FUW TRENDS IN SCIENCE & TECHNOLOGY JOURNAL
(A Peer Review Journal)
e–ISSN: 2408–5162; p–ISSN: 2048–5170
keywords: Ewan Community; Interleukin-10; Ewan; Cytokine Tumour necrosis factor-alpha (TNF-α); Schistosoma haematobium.
The researched evaluated the profile of interleukin (IL)-10 and tumor necrosis factor-alpha (TNF-α) of 35 volunteers infected with Schistosoma haematobium in Schistosomiasis endemic communities in Ewan, Akoko - Edo Local Government Area, Edo State, Nigeria. Serum IL-10 levels were significantly higher in Heavily positives than control subjects (P<0.001). The difference in serum IL-10 concentrations between Lightly, Moderately and Heavily infected stages of infection was statistically significant (P<0.001). The level of TNF-α for Lightly positive, Moderately positive and Heavily positive were significantly elevated when compared with the control subjects at χ2 =6.37, P>0.01; χ2 =22.79, P<0.001, χ2=35.57, P<0.001, respectively. The mean difference in serum TNF-α concentrations between this levels of infection was statistically significant (P<0.0001). We therefore suggest that the elevated levels of IL-10 and TNF-α may implicate these cytokines as mediators of host response to Schistosoma haematobium infection in the locality.
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